Mercury Detox program
Heavy Metal Detoxification and Chelation
A serious health issue we face today is heavy metal toxicity. Heavy metal are those types of metals which are more than five times as heavy as water. Some of heavy metals that can be toxic in the body are mercury, nickel, chromium, cobalt, beryllium are found in dental fillings , cadmium, aluminum, arsenic , lead ,these heavy metal can accumulate with the brain, kidneys, muscles and immune system where they disrupt normal function .mercury dental filings and oral bacteria convert to a highly toxic substance call methyl mercury. Once it has been leached from dental fillings and has infiltrated the body it becomes a neurotoxin.
The human body is very resilient to stress and toxins but it has limits, today our immune systems struggle under the burden of an ever-increasing load of man-made chemical and toxic metals.
As the body falls into a state of ill health and disease, elimination and removing toxins , toxic heavy metal and waste from the body becomes increasingly difficult. Retained debris can lead to absorption of toxins, resulting in systemic intoxication. As the boy moves toward better health through good nutrition , exercise, and health habits , healing can begin to occur. With new strength and stamina, the body may begin to discard the many toxic residues and toxic heavy metal that have built up over the years. For most people the cleansing reactions are very tolerable and pass within period of time, part of the time the patients may begin t feel better than he or she ever have. detoxification process depends on the toxic severity of patients condition and genetic constitution and individualized nutritional programs .
- VITAMIN C I.V. chelating agent.
- DMSA 500MG (2-3 dimercartosuccinic acid) This crosses the blood-brain barrier and thus help remove the remaining toxic residues form the central nervous system.
- DMPS (2-3 dimercaptopropane 1-1-sulfonate) I.V. Challenge Test .
- Chelating agent of choice for the removal potentially toxic heavy metal elemental mercury from the body can be given intravenously 205 mg I.V , orally 100/300 mg. The routine use of DMPS is not advisable for patients who still have silver amalgams fillings.
- EDTA I.V. chelating agent.
TESTING FOR MERCURY AND POTENTIALLY TOXIC HEAVY METALS
To evaluate the extent of your heavy metal body burden. DMPS I.V. Challenge Test, this test entails obtaining a “before” and after “ 24- hours urine toxic metals test “ , analysis of elements in urine provides diagnostic information on potentially toxic elements such as mercury, nickel, chromium, cobalt, beryllium are found in dental fillings , cadmium, aluminum, arsenic , lead assessment of toxic elements burden and essential elements wasting, monitors detoxification therapy .provide by DOCTOR’S DATA www.doctorsdata.com
Heavy Metal Detoxification
Joseph Mercola, D.O., Dietrich Klinghardt, M.D., Ph.D.
Journal of Nutritional & Environmental Medicine (2001) 11, 53-62
The most common source of heavy metal toxicity is from dental amalgam fillings and other metal dental appliances. In 1989, the Environmental Protection Agency (EPA) declared that amalgams are a hazardous substance under the Superfund law. Scrap dental amalgam was declared a hazardous waste in 1988 by the EPA. Outside of your mouth it has to be: 1. Stored in unbreakable, tightly sealed containers away from heat. 2. It is not to be touched. 3. Stored under liquid glycerine or photographic fixer solution. So, once it is taken out of the mouth it is toxic, but when it is placed in the teeth it is labeled "nontoxic." You can't throw it in the trash, bury it in the ground or put it in a landfill, but they say it's okay to put it in people's mouths. It sounds like truth decay! Lead, mercury and cadmium exert most of their toxicity by destroying important proteins, many of which are enzymes, hormones, or cell receptors. Mercury will attach to sulfur amino acid building blocks in proteins. The sulfur amino acids are methionine, cysteine, and taurine. Sulfur is present in all proteins. Numerous enzymes require intact sulfur groups and many are inactivated by mercury.
Lead binds with the sulfur groups on proteins and inactivates them. Lead suppresses neuron clusters in the brain, hindering brain development in children by stunting the mapping of sensory nerves. One of the primary ways the body gets rid of metal compounds is through a pathway that goes from the liver into the bile where it is then transported to the small intestine and excreted in the feces. Inorganic mercury is complexed with glutathione in the bile, suggesting that glutathione status is a major consideration in the biliary secretion of mercury. This same pathway is affected by a mercury induced reduction of available taurine needed to produce bile acid (taurocholic acid). When the microflora of the intestine has been reduced through stress, poor diet, use of antibiotics and other drugs, fecal content of mercury is greatly reduced. Instead of being excreted in the feces, the mercury gets recirculated back to the liver. The person that is under stress, eating a poor diet, and/or taking antibiotics will tend to maintain a higher body burden of mercury derived from dietary sources--especially if they are eating diets high in fish.
Disposal of the body's burden of mercury is via the urine and feces, although minute amounts are detectable in expired air. Excretion via the liver occurs in bile and reabsorption of some of this mercury does take place. However, the kidney is equipped with an efficient, energy-dependant mechanism for disposing of metals such as mercury. Kidney tissue contains a thiol-rich protein called metallothionein; exposure to toxic metals triggers the production of this protein which binds tightly to the metal, retaining it in the kidney tissue in a relatively harmless form. As long as the kidney's capacity for production of metallothionein is not overwhelmed, mercury excretion can eventually balance intake, thereby limiting worsening of symptoms. However, acute high doses of mercury, or an increase in the chronic dose level can readily precipitate renal failure, one of the classic symptoms of mercury poisoning.
Detoxification systems such as metallothionein, cytochrome P-450, and bile are adversely affected by mercury. Metallothionein binds toxic metals in the body to prepare them for excretion. Mercury ties up this material so it cannot clear out other metals such as lead, cadmium, and aluminum. Mercury from amalgam binds to -SH (sulfhydryl) groups, which are used in almost every enzymatic process in the body. Mercury therefore has the potential to disturb all metabolic processes.
A small proportion of total body mercury is excreted in various forms directly in the urine without being bound to protein. In low dose, steady state conditions, such as the dentist who has worked at a similar exposure level for years, the urinary output very accurately reflects the total body burden and this is why urine monitoring is so important.
The following is a list of nutrients that facilitate the removal of heavy metals.
- Mega H-: The negative hydride ions in Mega H- alter the water consumed with the food and supplements in our diet, to have a lower surface tension and an increased conductivity. A low surface tension in the extra cellular fluids is also important in the removal of toxins from the cells and into lymph and venous blood for removal from the body. Tap water has a surface tension of approximately 73 dynes/cm. The water around our cells has a surface tension of approximately 45 dynes/cm. It is necessary, that the body reduces the surface tension of water we consume in order for nutrients to pass through cell walls, and for toxins to pass out of the cells. Mega H- in water expedites this process. Glutathione: Contains cysteine, glycine and glutamic acid. The liver manufactures glutathione whenever extra cysteine is available. Blood glutathione levels change in direct proportion to the amount of cysteine is in the diet. One 50 milligram capsule or tablet, three times a day taken on an empty stomach. Individuals with insulin deficiency should not take glutathione.
- Methionine: Methionine levels are a major determinant in the liver's concentration of sulphur-containing compounds, such as glutathione and cysteine. As methionine is the precursor for the manufacture of cysteine in the body, extra supplementation of this critical amino acid should increase available cysteine. Animal studies have shown that methionine protects rats from the toxic effects of lead and mercury. Chelating agents such as DMSA (dimercapto succinic acid) and DMPS (dimercapto-propane sulfonic acid) bind to cysteine for excretion. L-cysteine bound to mercury (L-penicillamine, N-acetyl-L-cysteine, DMSA and glutathione complexed with methylmercury) resembles the L-methionine molecule and can cross the blood brain barrier. L-methionine inhibits the transport of these complexes into the brain. Methionine increases the bioavailability of glutathione. Most of the cysteine required for the resynthesis of glutathione must originate from methionine and not from cysteine generated by the catabolism of glutathione. Patients taking only D-L-methionine increased mercury excretion in the urine by 60% over the excretion rate before taking the methionine. Lead excretion was also increased. The L-form is rapidly metabolized by the liver and does not offer a sustained antioxidant level. Over half of the D-form is slowly metabolized by the same pathways as excess L, and acts identical to L as an antioxidant. The benefit of the D-L form of methionine is the D form provides sustained blood levels allowing he L-form to be converted to other sulfur antioxidants. Babies need 22 mg/Kg body weight of methionine on a daily basis while adults need 10 mg/Kg of body weight daily.
- N-Acetyl-L-Cysteine (NAC): NAC forms L-cysteine, cystine, L-methionine, glutathione (GSH), and mixed di-sulfides. Stimulates the body to produce large amounts of cysteine and glutathione, thus greatly augmenting plasma and red blood cell content of both cysteine and glutathione; Methylsulfonylmethane (MSM): MSM, like fresh garlic, provides a bioavailable dietary source of sulfur. MSM exerts a direct beneficial effect in ameliorating a variety of allergic responsees and pain associated with systemic inflammatory disorders.
- Milk Thistle (silymarin): Silymarin provides support and protection against liver toxins which can cause free-radical-mediated oxidative damage. Silymarin is many times more potent in antioxidant activity than vitamin E. In addition, it increases liver production of glutathione and protects red blood cell membranes against lipid peroxidation and hemolysis.
- Chlorella: Is a food-like all purpose mild chelator of heavy metals; it is a specially processed green-algae type of food that is taken with meals and is quite tolerable and pleasant for many. But since chlorella is so easily contaminated, the manufacturer’s quality control is important. Nature’s Balance is a source of high quality chlorella that can be taken as a part of a person’d detox program. The detoxification capability of Chlorella is due to its unique cell wall and the material associated with it. The cell walls of Chlorella have been shown to have three layers of which the thicker middle layer contains cellulose microfibrils. Atkinson et al found a 14nm thick trilaminar layer outside the cell wall proper which was extremely resistant to breakage and thought to be composed of a polymerised carotene like material.....Laboratory studies showed that there were two active absorbing substances - sporopollenin (a naturally occurring carotene like polymer which is resistant to degradation) and the algae cell walls." Chlorella's ability to detoxify the body is very significant because of the large amount of chemicals we are exposed to in today's modern world. This ability to detoxify chemicals is also one of the important differences between Chlorella and other "green" products."
- FRESH CILANTRO: Make Cilantro the first know substance that mobilizes Mercury from the CNS. The active principle is unknown.
- Dried Cilantro does not work in my experiences, which suggests that the active substance is in the volatile fat-soluble portion of the plant probably an aromatic substance.
- When autonomic response testing is used, rapid changes in the brain and spinal cord after Cilantro consummation can be demonstrated , also the appearance of Mercury in tissues where it was no previously found, i.e., liver, intestine as a result of mobilization in the nervous system.
- Parsley also works, but often has Gastrointestinal side-effects at appropriate doses. Stimulates the body's release of mercury and other heavy metals from the brain and CNS into other tissue. This facilitates the ability to remove heavy metal from the body using other dietary protocols, such as Chorella and other chlorophyll containing herbs such as Nettles and Alfalfa. These herbs aid in detoxifying by denaturing the toxins, protecting and restoring normal cellular functions while promoting elimination. The major constituents of the volatile oils are: myrcene (1.71%), d-linalool (52.26%), citronellol (4.64%), geraniol (9.29%), safrole (2.67%), aterpinyl acetate (1.07%) and geraniol acetate. A typical dose is orally 6-15 drops 1/2 hr. before or 1 hr. after meals 2x/day. For 5 days. 2 day rest and continue. Or Apply ¼ to ½ dropper on wrists, joints, or affected areas twice a day.
- Vitamin B6: needed in the metabolic process that converts methionine to cysteine and then into glutathione. B6 is capable of reducing and controlling the swelling and pain associated with the routine tissue and bone trauma resulting from normal dental operative procedures. You can also use Pyridoxal-5-phosphate (P5P), the active form that B6 is converted to in the body. Vitamin B1: is capable of reducing pain that may be associated with routine dental operative procedures. B1 is one of two vitamins containing sulfur, the other is Biotin.
- Magnesium: Magnesium availability is essential for the proper functioning of our immune system as well as hundreds of enzyme systems critical to human health. Organically amino acid-bound ones are more easily absorbed and are less irritating to the gastrointestinal tract as well.
- Activated charcoal: taken immediately with chlorella, 15 minutes before drilling/chunking out amalgam, will bind any swallowed mercury and also prevent recirculation in the liver.
- Refrain from taking any supplements that contain iron and copper. Mercury amalgam removal alone does not put an end to the mercury poisoning. The mercury which leached from the fillings in the mouth is stored in cells throughout the body and continues to exert its damaging influence. It is not unusual to see patients who have had their amalgam fillings removed and replaced ten to fifteen years prior to testing still having elevated levels of mercury in the body. Once mercury toxicity has been demonstrated, by tests such as high electro galvanism, high mercury vapor emissions, and/or high mercury body burden, mercury amalgam removal and replacement with alternate, non-toxic materials is the recommended step. Botanical substances to assist in removing the mercury include cilantro and chlorella which are particularly effective.
The skin is the body's largest detoxification organs and sweating can help draw mercury from the body. Saunas are a useful adjunct to safe mercury removal because they induce copious sweating. Initiate sweating and increased circulation by exercising 20 minutes three times a day on a rebounder (mini trampoline). Immediately following the exercise, sit in a sauna or under infrared lights (infrared sauna) for up to 30 minutes, then take a cool shower. The temperature from a "low heat" sauna should be between 140 to 180 degrees F. in contrast to the 200 to 210 degree F. for a non-therapeutic standard sauna. The sauna may be followed by a plunge into a bath or under a shower whose temperature is 65 degrees F. Over a period of three to four days, increase your time in the sauna to a total of up to two hours, divided into 30-minute periods with a short cooling-off period in between. It's important to shower and towel dry because the removal of sweat prevents reabsorption of toxins. While doing the sauna program, consume adequate amounts of water to avoid dehydration. this is a minimum of two quarts before and after entering the sauna. Replace your electrolytes lost to perspiration with grape or prune juice and drink vegetable juices to replace calcium and magnesium lost through the skin.
Oral Metal Chelation
NDF (Nanocolloidal Detox Factors)
Based on the results of comparative 24 hour urine samples analyzed by an independent clinic and lab, a person can safely excrete up to 920% (9.2 times) more heavy metals per month taking NDF daily as compared to doing one DMPS intravenous injection per month. This greatly shortens the time required to achieve detoxification, an average toxic adult person requiring a maximum dose of 2 mls. twice a day for a period of about two months. NDF also removes other toxins from the system.
The predominant route of excretion is via the urine, thus accelerating the excretion rate of the mobilized metals as compared to the fecal route, decreasing the possibility of enzyme and leaky gut mediated resorption through the bowel, and decreasing the burden on the liver. The majority of the metals to be mobilized and eliminated per dose are quickly detectable in the first urination following the dose. Fecal Element studies show an average of 38.4% reduction in fecal metals following 5 days at maximum dosage while urine levels remain elevated. Individual pathways of elimination have been noted. Independent real time digital EEG studies show a beneficial effect on the electrical activity of the brain, specifically raises the heavy metal suppressed beta waves to normal levels (from within 5 to 113 minutes post ingestion and lasting at least 4 hours) with a concurrent dramatic increase in the urinary excretion of heavy metals and patient reports of subjective improvement. This proves that no "healing crisis" is required during heavy metal detox while using NDF.
2 milliliters (2 droppers full or 52 drops) contain:
- 50 mgs. - Nanocolloidal cell wall decimated Chlorella Pyrenoidosa
- .12 mls. - Nanocolloidal Cilantro
- 10 mgs. - Nanocolloidal *PolyFlor
- 75 mgs/liter nanocolloidal Silica
- Grain neutral spirits 18% as a preservative
*PolyFlor microorganisms include: 12 strains of lactobacillus (including casei, acidophilus, salivarius, bulgaricus, sporogones and plantarum), 3 strains bifidobacterium including longum and bifidum, streptococcus thermophilus, and b. laterosporus.
Why "Nanonize" the Ingredients?
Chlorella is known in mining to bind heavy metals to its cell wall. Yet many people have taken Chlorella with no benefit. The reasons are that all of the available chlorella is not really "cell wall broken" and that most of it is already contaminated with heavy metals. Most of the cell walls are in tact, but the individual diatoms are tightly clustered in groups of about 500 units each. This is very difficult to digest and may explain why some people get gastro intestinal distress when taking normal chlorella but not with NDF. Nanocolloidal cell wall decimated chlorella has never been available so far! In addition to binding to heavy metals, Chlorella has other beneficial effects, augmented by putting it through this process, including: increased elimination of toxins, growth hormone regulation, a powerful nutritive impact and protection from radiation.
Why does it work?
The following is essential to the understanding of this supplement: The ingredients are in a nanocolloidal form. There is at least a 500-fold increase in available surface area and a dramatically reduced particle size, thus rendering each ingredient more bioavailable and effective. That means the effective bioavailable dose is roughly one five hundredth of the dose required compared to using a dose of the original ingredient. This is why 50 milligrams of nanonized chlorella achieves what 25 grams of normal chlorella cannot. Most toxin-burdened people have compromised assimilation and utilization and can't benefit from macromolecules.
In the past, Chlorella was only known to mobilize a small amount of heavy metals via the bowel. In NDF, because it is nanonized, "molecular components digested off the nano particles can be absorbed across the GI wall into the bloodstream and have a possibility to enter the brain depending on the molecule" - a possible explanation of why it can facilitate elimination via the urine.
PolyFlor contains fulvic acid. This could be the underlying reason why healthy bowel flora is so vital to good health. However, just taking a flora supplement will not provide heavy metal detox of the same magnitude as NDF (www.fulvic.com).
The major health benefits of both live and cell wall broken beneficial bacteria are described by recent clinical research in The Handbook of Probiotics. Lee, Nomoto, Salminen, and Gorbach. Pub. Wiley & Sons, Inc. '99. Unfortunately, once the amalgams are put into the teeth, or the toxic body burden becomes too great, or if a person only consumes processed and pesticide grown foods, these powerful allies no longer stand a chance of sharing their healing benefits with us.
Duration of Therapy
So far, only how much metal is being excreted can be measured, not the total body burden, so it is impossible to exactly predict the duration or cost of therapy. We do know that there is a linear relationship between the volume of the dose and the amount of excreted metals. Therefore, the more they can take, the quicker the detox will be. However, it is preferable to maintain the dose at the level that the patient continuously reports subjective improvement as a "healing crisis" is not required to effectively remove the heavy metals with NDF.
Cost Effectiveness / Compared to DMPS
It was recently determined by an independent, comparative 24-hour urine tests conducted by Dr. J. Wright via Doctors Data that a single, 2-dropper dose of NDF pulled out 20% as much metals as an IV dose of DMPS on the same patient. Since NDF can be taken daily, and DMPS only once a month (per the protocol presented by Drs. Klinghart and Mercola), this means that up to 920% (9.2 times) more metal can be excreted per month using 2 droppers of NDF twice a day (maximum dose) without the side effects and mineral deficiencies associated with DMPS. Since there is a linear relationship between amount of the dose and percentage increase in excreted metals, 6 drops twice a day would take out about 107%, or roughly the same amount of metals per month as DMPS, making NDF very cost effective, especially when you consider that very little additional supplementation is required while using NDF. Suggested retail is now $150 for a one-month supply, equal to the cost and efficiency of one DMPS IV push.
New Delivery Method for Chelation Therapy
The newest, easiest, most convenient and efficacious technique for detoxifying heavy metals out of the body is by means of rectal chelation therapy. The method is to self-apply Detoxamin, a patented, trademarked and registered over-the-counter suppository. People exhibiting toxic metal burdens now are able to chelate themselves while sleeping by use of this non-prescription chelator. Merely insert the firm gelatin pill into the rectum, go to sleep, and awake in the morning partially detoxified. Repeat the procedure until testing show that there is no more metal poison remaining in the body. With this suppository method, the main obstacle to intravenous EDTA chelation therapy has been eliminated. Rather than spending three or more hours per infusion session in a clinic, hooked to an IV, you may take less than a minute to insert the Detoxamin suppository at home before bedtime. Since many people cringe at the thought of getting stuck with a needle for twenty or more such IV treatments, use of a suppository eliminates this psychologically stressful and time-consuming obstacle. Rectal administration is less invasive, in no way uncomfortable, and generally greatly preferred over IV treatments.
Taking 3-5 suppositories over a 30-day period. This is medically equal to approximately 2-EDTA IV treatments. When on Detoxamin maintenance one box of Detoxamin lasts 6 to 10 months. Taken every night for 90 days or every other night for 180 days provides the medical equivalence of approximately 30 IV Chelation treatments.
Rectal chelation therapy does the job of detoxifying in a low-cost way to effuse EDTA through the bowel’s walls and into your blood stream to clean toxic metals from all body cells. Detoxamin has a time-release mechanism that allows the EDTA to absorb through the colon wall over an eighty-minute period while you sleep. Almost all the blood from the rectum makes its way to the superior hemorrhoidal veins, a tributary of the portal system, so that absorption through the rectal wall carries the EDTA in Detoxamin to the portal vein.
The lower and middle hemorrhoidal veins bypass the liver-and do not undergo first pass metabolism. This means that the EDTA in Detoxamin goes directly to the organs of your body without being filtered through the liver first. Because of this, the EDTA contained in Detoxamin is very productive. Detoxamin also introduces EDTA directly into the systemic circulation, efficiently bypassing the portal circulation and the liver metabolism on the first pass. Rectal absorption may also occur through the lymphatic system and, in some cases, largely through the blood via the vena cava.
Detoxamin offers many advantages both over the expensive intravenous method of EDTA chelation. With the use of needles via the intravenous method, and risk of AIDS and other communicable blood-borne diseases, Detoxamin is becoming the logical choice over I.V. EDTA chelation and the poorly absorbed oral EDTA. The rectum has a more neutral pH and is not as acidic as the stomach, which makes this area much better for EDTA absorption because it is not buffered and has a neutral pH, unlike the stomach. It also has very little enzymatic activity, thus enzymatic degradation does not occur. The rectal mucosa (rectum) is much more capable than the gastric mucosa (stomach) of tolerating various drug-related irritations. This is why patients who can't tolerate oral pain medication are given the same medication in suppository form. In fact, absorption with any oral EDTA tablet is so low that 135 (500mg) oral EDTA tablets are equal to just 5 Detoxamin suppositories.
Detoxamin removes most harmful toxins from the body, safely and effectively. Detoxamin is taken at night prior to bedtime, each Detoxamin suppository contains 750mg of Calcium-disodium EDTA, and is made in a cocoa-butter base (melts on body contact), which is very therapeutic for the rectal mucosa and the colon wall. The Ca-sodium form is able to bond (chelate) effectively because it does not lower the blood pH to a level that would prohibit the bonding action. The Ca added to the salt is important in this mode of administration as it buffers the acidic quality of the active ingredient keeping the suppository from being abrasive to the mucous membrane of the rectum area. Ca-disodium EDTA has both a scientific justification for therapeutic effectiveness as well as a clinical history of effectiveness.
The Calcium EDTA in Detoxamin has an extra chemical bond compared to the older Disodium EDTA. This gives Detoxamin EDTA an affinity for Mercury. Mercury is also excreted from the body through the feces and, because Detoxamin utilizes the colon wall for EDTA assimilation; it is a powerful Mercury chelator.
Metal Removing Nutrients
Calcium & Vitamin C: Just as lead will displace calcium, calcium is an excellent nutrient to utilize for displacing mercury and lead. Utilizing a combination of minerals, such as magnesium and calcium, is even more effective in clearing metals from the body. Increasing vitamin C intake is a reasonable cost-effective way to control toxic metal levels in the population. Several studies implicate lead in causing cavities, and at least one study suggests that almost 3 million cavities in children result from lead. Vitamin C and Calcium supplementation are recommended for protection.
Chlorophyll: chlorophyll binds to heavy metals very well. In fact, it is imperative to choose a reputable source for your chlorophyll, which screens for toxins and heavy metals; or you may be getting more than you want. A good source is juiced raw, organic greens.
Fiber: Fiber, such as oat bran and apple pectin, will bind to metals and help draw them out of the body. Montmorillinite clay also binds extremely well to toxins and metals for clearance. Fiber such as red beet root fiber is high in proanthocyanidins and antioxidants and facilitates clearance of metals through the liver.
Lipoic Acid: Lipoic acid is a potent antioxidant and has a high affinity for binding to metals. This makes it an excellent choice as a supplement to bind and clear mercury and lead from the system. It is best utilized in combination with conjugating nutrients.
Minerals: A mineral-rich diet acts as a chelating agent. Many minerals will chelate metals, including calcium, magnesium, zinc and selenium. Mercury interferes with some functions of selenium, including its powerful antioxidant function and its ability to bind to metals. A good source of bioavailable minerals is from raw sea vegetables and grass juices from wheat, barley, alfalfa, kamut, etc.
Milk Thistle (silybum marianum): Milk thistle is a renowned liver herb, and supports this major detoxification organ. Milk thistle contains silymarin, a bioflavonoid that is a very potent remedy for the liver. Silymarin inhibits free radical damage; free radicals have an adverse effect on the detoxification enzymes of the liver cytochrome P450 system, while silymarin protects those enzymes. Glutathione is destroyed by lead. Silymarin not only prevents the depletion of GSH (glutathione), it even increased this liver-detoxifying enzyme. A sulfur pathway in the liver detoxes lead, and milk thistle helps to boost liver function.
Molybdenum: Large amounts of exogenous sulfur (from outside the body) will usurp the body's stores of molybdenum to metabolize it. An easier solution is to use the nutrients which will facilitate the homocysteine pathway. Homocysteine is a toxic substance, however the pathway itself, when properly supported, is essential for a host of metabolic functions. When the pathway is facilitated, sulfur is generated as a natural by-product at the end (molybdenum changes the toxic sulfite molecule to the much-needed sulfate). Vitamins B12, B6 and folic acid, along with trimethylglycine and dimethylglycine recycle homocysteine to methionine, and allow for Sam-e to methylate phosphatidylserine, an important brain nutrient. Usually the people who are the most deficient in sulfur will be the most sensitive to metal toxicity and vice versa.
Parotid Glandular: Parotid glandular is believed to accelerate the clearance of chemicals/heavy metals from tissues. It is best utilized in combination with detoxification nutrients that will pull the metals out of the body by detox pathways such as the bowel, kidney, lymph, lungs, blood, skin, and liver.
Sulfur: Lead, mercury and cadmium steal sulfur from important proteins, which could be enzymes, hormones, or cell receptors. Conversely, sulfur is needed in the liver detox pathway to hook onto these metals and clear them from the body. So, lead, mercury and cadmium depletes sulfur, the very nutrient needed to detox the metal overload. A depletion of sulfur will also adversely affect joint connective tissue growth, since sulfur is an essential precursor to the building blocks of cartilage, namely glucosamine sulfate, chondroitin sulfate, and hyaluronic acid. Good sources are egg yolks, garlic, kelp, kale, turnip, raspberries, onions, cabbage, and mustard.
Zinc: Zinc and copper get displaced from metallothionine, the protein that binds and carries them. This destroys many of the zinc-dependent enzymes. Zinc is important for proper functioning in a host of major metabolic pathways; it is a component of over 90 metalloenzymes in the body. Lead has always been known as a neurotoxin, with the brain being particularly susceptible to attack. Lethargy is a common symptom of lead toxicity; lead inactivates the zinc-dependent enzymes of the Kreb's cycle, which produces our energy. Zinc is also a part of the antioxidant enzyme, Zn-SOD, which fights superoxide radicals. Symptoms of lead toxicity are similar to zinc deficiency symptoms because lead can bring on a zinc deficiency. Zinc deficiency has been implicated in a wide variety of neuropsychiatric disorders, including dyslexia, epilepsy, mental depression, and attention deficit disorder. The symptoms of lead toxicity are similar to zinc deficiency because the lead destroys the zinc-dependent enzymes.
Mercury Toxicity and Systemic Elimination Agents
Joseph Mercola, D.O., Dietrich Klinghardt, M.D., Ph.D.
Journal of Nutritional & Environmental Medicine (2001) 11, 53-62
We are seeing a serious rise in the environment of neuro-toxic chemicals and heavy metals. The resultant accumulation of heavy metals in the human body poses significant health risks. Chronic mercury exposure from occupational, environmental, dental amalgam, and contaminated food exposure is a significant threat to public health. A single dental amalgam filling with a surface area of only 0.4cm is estimated to release as much as 15 micrograms of mercury per day primarily through mechanical wear and evaporation. The average individual has eight amalgam fillings and could absorb up to 120micrograms of mercury per day from their amalgams. These levels are consistent with reports of 60micrograms of mercury per day collected in human feces.
By way of contrast, estimates of the daily absorption of all forms of mercury from fish and seafood is 2.3 micrograms and from all other foods, air and water is 0.3 micrograms per day.
The mercury vapor from the amalgams is lipid soluble and passes readily through cell membranes and across the blood brain barrier. iv It is scientifically clear that amalgam mercury transfers to human tissues, accumulates with time, and presents a potential health threat. The scientific evidence is so overwhelming that, in 1994, the United States Public Health Service declared that mercury amalgam exposure was higher than their established minimal risk level standard for the general population.
The U.S. Public Health Service and the American Academy of Pediatrics recommendation in July of 1999 to remove the mercury in the accines administered in the U.S. also demonstrates the U.S. government’s recognition of mercury as a toxic agent. v A “silver” filling, or dental amalgam, is not a true alloy. Amalgams are made up of 50% mercury, which is not, as most dentists believe, locked into the filling. Rather, the mercury escapes continuously during the entire life of the filling in the forms of vapor, ions and abraded particles. vi Chewing, brushing, and the intake of hot fluids stimulates this release. The absorption rate of inhaled mercury vapor is extremely high, with approximately 80% of the inhaled dose reaching the brain tissue within one blood circulation cycle. The amalgam also consists of 35% silver, 9% tin, 6% copper and a trace of zinc.6 More than 100 million mercury fillings are placed each year in the U.S. as over 90% of dentists use them for restoring posterior teeth. Statements made by the dental profession, which claim that the amount of mercury exposure encountered by patients from dental amalgams is too small to be harmful, are contradicted by the scientific literature and are totally indefensible . Dentists do not receive training that would enable them to monitor for symptoms related to mercury toxicity. The fact that mercury amalgam fillings are banned in many countries in Europe is strong evidence of the clinical toxicity of this material. Any metal restoration placed in the mouth will produce electrogalvanic effects. These subtle electric fields will adversely affect brain function. Brain cells have electric potentials of approximately one millivolt (millionth of a volt) and they communicate with each other through these minute electric fields. The current that is generated by metal restorations in the mouth (electrogalvanism) is far greater than the current that runs the brain. Ideally, the mouth should be metal restoration free to minimize these potentially disturbing influences, which will interfere with optimal brain function. Even if the metal is biocompatible and properly placed with no occlusion problems, the metal in the mouth will impair some elements of optimized brain function.
From a scientific point of view, there is no more “controversy” about the ill health effects of dental amalgams. There is no debate about the fact that mercury in the central nervous system (CNS) causes psychological, neurological, and immunological problems in all humans.xii,xiii These symptoms and literature are carefully reviewed elsewhere.xiv The sheep and monkey studies conducted at the University of Calgary, Canada-under the guidance of Dr. Murray Vimy -showed that radioactively labeled mercury released from freshly and correctly placed amalgam fillings appeared quickly in the kidneys, brain and wall of the intestines.xv, Mercury bonds very firmly to structures in the nervous system through its affinity for sulfhydryl-groups on amino acids.
Other studies showed that mercury is taken up in the periphery by all nerve endings and rapidly transported inside the axon of the nerves (axonal transport) to the spinal cord and brainstem.xvi Laboratory studies have shown that within 24 hours of injecting a minute dose of mercury into a muscle anywhere in the body it is quickly present in the spinal cord and brain. The mercury was also present in the kidneys, lungs, bloodstream, connective tissue, adrenal and other endocrine glands. In the brain, it tended to congregate in the hypothalamus, which regulates the sympathetic nervous system, and in the limbic system. Mercury vapor is hydrophobic or lipophilic and does not bind with oxygen and transfers directly into the tissue. Mercury also migrates from the teeth into the tissues through the process of chewing that converts small amounts of amalgam into mercury vapors and particles that are swallowed and absorbed in the GI tract. This is metallic mercury and easily penetrates all cells. Catalase is an enzyme in the cell attaches mercury to a sulfhydryl group inside the cell. Mercury is taken up into the lymphatics, into the veins, and then runs into the gut, and then to the liver, and then into the gallbladder. Mercury then dumps back into the gut and recycles. This is called enterohepatic circulation. Mercury also is absorbed in the lymphatics of the lower jaw, which go straight into the cervical lymphatic chain and into the thyroid, and then dumps into thoracic veins. Lymphatics of the upper jaw are continuous with the brain and, within seconds, mercury absorbed there goes directly into the brain. The half-life of mercury in the body is suggested to be about three to six weeks, but that is because it is not measured in the tissues. Mercury does not appear to have a “half-life” in the central nervous system as it binds relatively non reversibly with CNS tissue. Mercury, once in the nervous system, stays there permanently, unless it is detoxified.
Tubulin forms tubular structures within each nerve, along which the nerve-cell transports metabolic waste from the nerve cell into the periphery and along which the nutrients required by the nerve cell are transported from the periphery to the cell. Mercury contributes to further toxicity on its route to the CNS from the periphery by immobilizing the enzyme that is essential for “making” tubulin. Once mercury has traveled up the axon, the nerve cell is impaired in its ability to detoxify and nurture itself. All of the nerve nutrition is through the nerve ending and travels up the tubulin into the cell nucleus through the axon. The mercury-contaminated nerve cell becomes toxic and lives in a state of chronic malnutrition if it is able to survive this toxin. This is due to mercury’s inhibition of the polymerization of tubulin, which is essential for the formation of microtubules. Mercury, in all of its forms, is a powerful neuro-toxicant that can destroy the tubulin molecules when it is taken up by the nerve synapse through the mucous membranes in the mouth. Inorganic mercury inhibits the function of tubulin, a critical protein for the brain to perform properly.
Mercury Toxicity Symptoms
The overt clinical effects resulting from toxic exposure to mercury have been clearly described. The scientific literature shows that amalgam fillings have been associated with a variety of problems such as autoimmunity, kidne dysfunction, and interference with the immune system as measured by the T-lymphocyte count. Patients with many amalgam fillings will also have an increase in the prevalence of antibiotic resistant bacteria. Subclinical neuropsychological and motor control effects were also observed in dentists who had documented high mercury exposure levels. Amalgam use may also be related to fatigue, poor memory and certain psychological disorders. The presence of infertility has increased from 8 to 15% over the past two decades, which may be related to mercury exposure. Heavy metals induce modifications of neurotransmitters in the central nervous system and impair the pulsatile hypothalamic release of gonadotropin-releasing hormone. Dental assistants were found to have half the conception rate compared to women without mercury exposure. Removing the mercury seems to be associated with an improved fertility rate.2 There is also an increased rate of hormonal disorders among women exposed to mercury. Polycystic ovary syndrome as a result of mercury exposure has also been described. The earliest symptoms of long term, low level mercury poisoning are subclinical and neurological.Subsequently, due to their subtlety, these symptoms are easily misdiagnosed. Intracellular mercury can cause chronic fatigue, cancer and learning disabilities. Extracellular symptoms of mercury toxicity include: CNS irritability, anxiety, nervousness, fearfulness, emotional instability, loss of self-confidence and shyness. In adolescents, these symptoms are particularly damaging as they impair one's normal social development. Additional symptoms may include: loss of memory, especially room-to-room memory, impaired concentration, and insomnia. It is well documented that lead and cadmium can cause hypo or hyperthryoidism.. Mercury toxicity will also tend to cause hypothyroidism. The most frequent cause of hypoglycemia is excessive sugar and grain consumption. However, it can also be exacerbated by mercury toxicity. Mercury toxicity can also increase food allergies. Detoxification of mercury will frequently improve these allergies. Additionally, fibromyalgia pain, which is frequently experienced as areas of numb and burning pain, is improved with mercury detoxification. Mercury and Chronic Infections.
As referenced above, mercury clearly has a variety of detrimental impacts on the immune system. Many practitioners have long observed that patients diagnosed with chronic viral illnesses (EBV, CMV, HIV, herpes zoster and genital herpes, CFIDS, etc.), chronic fungal illnesses (Candidiasis and others), and recurrent episodes of bacterial infections (chronic sinusitis, tonsillitis, bronchitis, bladder/prostate infections, HIV related infections) often have dramatic recoveries following an aggressive mercury/amalgam detoxification program.36This would support a general immune enhancing benefit of any effective mercury detoxification program. It has also been shown that the presence of amalgam fillings conveys immunity to antibiotics to various bacteria and also impairs the body's own defense system. Mercury is, therefore, the only substance ever shown that induces antibiotic resistance in bacteria, other than an antibiotic itself.78 It is known that bacteria cause periodontal disease and that the removal of amalgam fillings can often be curative.77 Unfortunately, there are no studies to date that have tested the mercury hypothesis in other infections, even though the clinical evidence is overwhelming.
Testing —The Diagnostic Dilemma
It is important to note that prior to beginning any detoxification protocol one should perform a chemistry profile to test for kidney and liver function. Mercury, once it is released into the body, is quickly and firmly bound in the peripheral and central nervous system (brain, spinal chord, peripheral motor and sensory ganglia, autonomic ganglia). Except for a short period after acute exposure, mercury’s rapid transport to the nervous tissue dramatically limits its presence in the blood, hair, urine, feces, sweat or any other body fluids . Therefore, a regular trace-element analysis of any body compartment (hair, whole blood, or red cell) will generally not show any evidence of mercury toxicity unless the patient is actively detoxifying mercury. However, there are three traditional tests used for mercury diagnosis.
- Porphyrins. The most accepted test for metal toxicity in the traditional medical community is the determination of porphyrins in the urine.37 Certain porphyrins are elevated in blood and urine.
- Hair analysis. One must use this test with caution though. One could have a result showing low levels of mercury yet have high levels in their tissues. One can do a hair analysis six weeks after starting a mercury detoxification program and it should be high in mercury, which suggests that the mercury is transferring from the tissues into the blood and being excreted into the hair follicles.
- Challenge tests with complexing or chelating agents (administration of appropriate agents followed by mercury urinalysis). Chelation involves the incorporation of a metal/metalloid ion into a heterocyclic ring structure. A chelating agent forms a ring structure with a metal or metalloid. A metal complexing agent is a more general term, which includes a chelating agent. When used for treating heavy metal poisoning, the administration of the chelating agent results in the formation of a chelate structure. The chelating agent usually has a greater affinity for the metal ion than do endogenous ligands to which the offending metal is bound. The metal chelate usually has water solubility greater than that of the offending metal ion and thus increases it excretion by the kidney.
DMPS and DMSA Chelation Challenge Test
The use of a provocative or challenge test for estimating the body content or exposure to a heavy metal is well established in medicine. The challenge test may need to be performed before beginning amalgam removal for legal documentation. However, many clinicians' experiences have shown that when a patient is mineral deficient (especially sodium, calcium, potassium or sulfur), the body is unable to mobilize toxic metals with a challenge test. The mineral status needs to be corrected prior to successful mobilization for mercury. Chelation challenges are generally done with DMPS and DMSA, which are chelating or complexing agents. The first suggestion for the use of DMPS as a provocative or challenge test for mercury was made in 1981.38 It was first used in the western world in 1988.39 The patient is generally given a dose of one or the other immediately after emptying their bladder. DMPS-stimulated excretion of all heavy metals reaches a maximum after 2-3 hours and decreases thereafter to return to baseline levels after 8 hours.40 So the urine is collected for and analyzed for mercury content. Most of the mercury will come out relatively quickly so many physicians will have the patient wait in the office or go out to lunch and then come back in 90 minutes after the chelation and collect the urine specimen. It is important to remember that mercury is heavier than water. So when taking an aliquot from the urine sample, it is helpful to shake the sample first prior to pouring it into the container that will be sent to the lab for analysis. If using the DMSA challenge, one should collect the urine for six hours. DMPS is more potent than DMSA, thus a significant urine level of mercury with DMPS would be above 50 mgs while with DMSA, 10 or more mgs would be considered a significant amount.
Basics of Treatment
One of the essential initial steps of therapy is to optimize the diet BEFORE metal detoxification starts. One needs to decrease processed foods, stress and sugar. It would be best to limit fluids to water exclusively and minimize or eliminate all sugar, milk and wheat. These changes will improve immune competency and the body’s ability to tolerate the detoxification process. More details are available in the Reaching for Optimal Wellness article. The latest version can be found on the Internet at www.mercola.com. It is listed under a button called “Read This First” on the home page.
Metals are stored in many different body compartments. Each compartment requires different detoxification approaches. The different compartments are intracellular, extracellular (connective tissue), intravascular, kidneys or gut wall and central nervous system. Chlorella is used to shuttle mercury out of the gut. Chlorella and DMPS41,42 have powerful detoxification abilities on the connective tissue. It is important to begin detoxification by first unloading the connective tissue. This is best achieved with chlorella. When this is accomplished, one can then begin intracellular detoxification. DMSA or cilantro will move mercury out of the cell and brain. Sulfur containing substances like garlic,43 DMPS or DMSA will mobilize mercury out of the kidneys. Muscle testing has shown that during mercury detoxification large amounts of mercury are not only excreted via the kidneys but also appear in the small intestine/upper colon (especially when Chlorella and Cilantro are used). They are excreted both via the liver-gall bladder-small intestine pathway, as well as through direct active and passive transport from the intestinal vessels into the lumen. However, the excreted stool contains a much lesser amount of mercury than the lower part of the small intestine/upper part of the large intestine. This suggests re-absorption of mercury during its passage through the colon.
Algae and other aquatic plants possess the capacity to take up toxic trace metals from their environment, resulting in an internal concentration greater than those of the surrounding waters. This property has been exploited as a mean for treating industrial effluent containing metals before they are discharged, and to recover the bioavailable fraction of the metal.44 Chlorella has been shown to develop resistance to cadmium contaminated waters by synthesizing metal-binding proteins.45 A book written for the mining industry, Biosorption of Heavy Metals, details how miners use organisms called biomasses to increase the yield of precious metals in old mines. These biomasses are sprayed into the mineshaft, washed out with water, and collected on ion exchange membranes. A biomass is a sludge of membranes usually from mono-cellular organisms that have a tendency to accumulate metals that they are exposed to in their outer cell wall. Dr. Klinghardt believes that most, if not all chronic infectious diseases are not caused by a failure of the immune system but are a conscious adaptation of the immune system to an otherwise lethal heavy metal environment. Mercury suffocates the intracellular respiratory mechanism and can cause cell death. So, it is speculated that the immune system makes a compromise: it cultivates fungi and bacteria that can bind large amounts of toxic metals. This allows the cells to breathe. However, the system is compromised, as it has to provide nutrition for the microorganisms and has to contend with their metabolic by-products (“toxins”). These organisms, especially Candida, can frequently grow uncontrollably. When this occurs, the patient experiences the so-called “die-off effect” (the sometimes severe crisis or even lethal reaction a patient can have in the initial stages of aggressive pharmaceutical antifungal or antibacterial treatment). This is often due to acute heavy metal toxicity-metals released from the cell walls of dying microorganisms.
The list of organisms that have the highest affinity for toxic metals covers the full spectrum of typical infectious diseases: fungi of the candida species, streptococci, staphylococci, and amoebas, among many others. However, two algae top the list of organisms in their ability to effectively bind to mercury: Chlorella pyreneidosa and Chlorella vulgaris. Although spirulina and super blue green algae are also algae with other health benefits, the mining and clinical research does not support their use in binding these heavy metals.
Chlorella appears to have two significant mechanisms of action that make it an ideal agent to be used in a toxic-metal treatment protocol. Its cell wall absorbs rather large amounts of toxic metals (similar to an ion exchange resin). Either the specific combination of amino-acids, the chlorella derived growth factor, or some other yet unknown mechanism leads to mobilization of some mercury from within the cell. It enhances mobilization of mercury compartmentalized in non-neurologic structures such as the muscles, ligaments, connective tissue, and bone.
Chlorella is an essential part of the detoxification program, as approximately 90% of the mercury in our bodies is eliminated through the stool. To increase the fecal excretion of mercury, certain principles should be applied. First, it is wise to first start the mercury detoxification by first unloading the connective tissue with chlorella. Large doses of chlorella will clear out the mercury that can frequently contaminate the colon. Chlorella works likes a sponge to suck up mercury from the body. Chlorella only pulls mercury out of the gut wall. Once the gut is cleared, the mercury will then, by osmosis, go into the gut from other body tissues where chlorella will effectively remove it from the body.
The powder is the most cost effective approach but some people will prefer the tablets or capsules for convenience. One can start out with a one quarter of a teaspoon of the powder (one 500 mg tablet) once a day initially to confirm that there is no hypersensitivity present. Work up to 3/4 of a teaspoon (5- 500 mg. tablets) with every meal. Every tenth day you can take a large dose of one tablespoon (16- 500 mg tablets) with each meal. A simple way to dissolve the powder is to place it in a container with a lid partially filled with water. Then tighten the lid and shake to dissolve and drink the solution. Most people find it inconvenient to spread the doses out to include the lunch meal. Therefore, one could possibly increase the normal daily dose to 1 1/2 teaspoons with breakfast and dinner for convenience.
CAUTION: If at any time one develops nausea or starts "burping up" the chlorella taste then the chlorella should be stopped immediately as a food sensitivity is developing which will only worsen if you continue taking it.
Chlorella is also very helpful for removing radioactive metals or fallout. Amalgam tattoos are black deposits on the gum and cheeks that are due to mercury deposits. These are typically removed surgically. Chlorella can be used to remove the amalgam tattoos noninvasively by sticking the chlorella powder on a cotton roll and placing it on the tattoo overnight. The treatment requires about two weeks to remove the tattoo.
Dr. Omura has found that Cilantro (Chinese parsley) can mobilize mercury and other toxic metals rapidly from the CNS and the brain when appropriate amounts are consumed daily.46 47 Cilantro mobilizes mercury or tin stored in the brain and in the spinal cord and moves it into the connective tissues, Cilantro is especially useful for removing mercury from the brain, as brain detoxification is one of the most difficult to achieve. The mobilized mercury appears to be either excreted via the stool, the urine, or translocated into more peripheral tissues. This is a revolutionary discovery and makes cilantro the first known substance that mobilizes mercury from the CNS. The active principle is unknown. Dried cilantro, however, does not work which suggests that the active substance is in the volatile fat-soluble portion of the plant. It would be wise to use fresh cilantro as a seasoning four to five times a week. A pesto can also be prepared by purchasing fresh organic cilantro and putting it in a blender with a small amount of water, sea salt and olive oil. Blend this until creamy.
Take 1 tablespoon 3 times/day with meals. A tincture is also available and the dose is ten drops three times a day, however, the commercial distillates are not as cost effective as using the fresh herb.
Coriander may also be similarly useful although it is not as well studied. Cilantro does not facilitate the removal of heavy metals out of the body; this usually requires DMPS or DMSA with Chlorella and sauna treatment. The use of Cilantro with DMSA or DMPS has actually been documented to show an increase in motor nerves following DMSA or DMPS administration.
This is a special form of chlorophyll from Biotics Labs that seems to be especially useful for mercury detoxification. It consists of a group of different porphyrins that facilitates metal excretion. In nature, porphyrins are used to shuttle metals to different systems. The porphryn ring structure of chlorophyll, which contains magnesium, is similar to the porphryn ring structure in hemoglobin, which contains iron.
Porphrazyme can assist mercury removal and is generally taken one to three tablets three times a day for one to two years.
It is important to have a generally healthy mineral base. It appears that the body works better with toxic metals than no metals at all. Enzymes have certain binding sites that require a metal for them to perform their function as a catalyst. When patients are deficient in magnesium, sodium, zinc and other minerals, the body does not let go of the toxic metals very easily. A person with mercury contamination of ten becomes zinc deficient and the functioning of copper and other minerals in the body will be compromised as well. So, it will be important to have a healthy mineral base. Selenium,49,50, 51 is a particularly important trace mineral in mercury detoxification and should be used for most people.
If a person does not have a sufficient amount of hydrochloric acid secreted by their stomach then it will be very difficult to ionized mineral supplements to absorb them properly. There is a sternal reflex present on the lowest rib approximately one inch lateral to the midline. If this area on the rib is tender to palpation there is a strong likelihood the person is deficient in hydrochloric acid and would benefit from supplementation. This is especially common in individuals over 50 years old, and also in individuals with food allergies. One to six capsules of Betaine hydrochloride is generally taken with the first bite of every meal for proper digestive support. The Betaine can be discontinued once the reflex point in nontender to deep palpation.
Optimize Bowel Flora.
It will be important to consider use of a probiotic that has more strains than just Lactobacillus acidophilus. Consider using one that has many different strains and in high concentration or one of the preparations that have soil based organisms such as Bacillus subtilis. There is some concern that FOS used in many products may be counterproductive by encouraging the growth of certain pathogenic anaerobes such as Klebseilla. There is some suggestion that soil-based organism products may be particularly useful in recolonizing the gut.
Optimize Bowel Transit Time
One should make certain that the patient is having two to three bowel movements per day. This will decrease the likelihood for mercury reabsorption during the detoxification process. If the patient is having less than that number, it will be important to have thyroid function checked. The most sensitive assessment would be a TSH, Free T3 and Free T4. A TSH level above 1.5 suggests hypothyroidism, while Free T3 and Free T4 levels in light of a normal TSH below 1.5 could suggest pituitary or hypothalamic hypothyroidism. If the thyroid function is normal, one should use large doses of magnesium glycinate or citrate or vitamin C to increase the stool frequency. However, it is important not to have loose stools, as this would be counterproductive.
MSM (Methyl Sulfono Methane)
MSM is a form of organic sulfur; it is similar in many ways to DMSO. All the mercury detoxification agents, with the exception of chlorella and cilantro, work by facilitating mercury’s binding to sulfhydryl groups. Most patient’s sulfur systems are greatly depleted as a result of detoxifying environmental toxins and excreting sulfur in the gallbladder and intestine. Typical available sulfur stores are not sufficient to cope with the environmental stresses to which we are exposed. Because of this depletion, we cannot utilize the chelating sulfur agents until we restore our sulfur stores Unless this sulfur is replaced when one uses sulfur based chelating agents like DMPS or DMSA, the body will use the sulfur from the chelating agent. The chelating agents will thus be impaired and converted to a non-functional status, thus unable to bind to mercury. They will, however, function as an extraordinarily expensive sulfur supplement. If we use DMPS or DMSA without preloading sulfur stores, the body will use the sulfur in the DMPS or DMSA and break it down before it uses it to bind to mercury. So, it is necessary to build up sulfur with products like MSM. The initial dose is a half-teaspoon or half capsule once a day. One then slowly works up to one capsule or one teaspoon twice a day. If one uses MSM, garlic is unnecessary, as the main purpose of both MSM and garlic is to supply organic sulfur.
Essential Fatty Acids
Most people are deficient in these vital nutrients. Many employ flaxseed oil as a strategy to address this deficiency. However, this strategy can backfire for most people. This is easily determined by noticing any nausea after consuming flax oil. Nausea is a powerful indication that the supplement should not be used. It is likely that inhibition of the delta 6-desaturase enzyme by excessive grain ingestion with its secondary hyperinsulinemic actions will impair proper metabolism of the flax oil. High levels of alpha linoleic acid build up which impair fatty acid biochemistry. Generally, one to two tablespoons of whole flaxseed that is ground in a coffee grinder immediately prior to using seems to circumvent this problem.
It is generally safe for most people to use Evening Primrose Oil as the preferred essential fatty acid, as it is high in gamma linolenic acid (GLA) and does not have other fatty acids present that can disrupt fatty acid biochemistry. Although borage oil is less expensive, most people have problems with the nervonic acid levels in borage oil. The GLA in the Primrose Oil should be balanced with the EPA/DHA from fish oil capsules in a 4:1 ratio. The dose of the GLA should be about 250 to 1000 mg per day.
Vitamin E is also helpful. Many physicians believe the Unique brand vitamin E is one of the better options available as it uses a high-grade material of mixed natural tocopherols. One of the 400 unit capsules should be more than sufficient. Vitamin C is also a helpful supplement for detoxification52 and doses are about 500 mg, three times a day.
DMPS (Sodium 2,3-dimercaptopropane-1-sulfonate) is an acid with a free sulfhydryl group that forms complexes with heavy metals such as mercury, cadmium, arsenic, lead, copper, silver, and tin. It is a water-soluble complexing agent. It was developed in the former Soviet Union by Petrunkin53 and has been used to treat metal intoxication since the 1960s in the former Soviet Union. Because it had potential use as an antidote for the chemical warfare agent Lewisite it was not available outside of the Soviet Union until 1978, at which time Heyl, a small pharmaceutical company in Berlin, Germany started to produce it. It has an abundance of international research data and an excellent safety record in removing mercury from the body and has been used safely in Europe as Dimaval for many years.I It is registered in Germany with the BGA (their FDA) for the treatment of mercury poisoning and in fact is available in Germany without the need of a prescription.
American toxicologists working with Iraqi physicians first used it for treating people who had eaten bread prepared from grain seeds that had been treated with a mercury-containing fungicide. The use ofDMPS to treat mercury toxicity is well established and accepted. DMPS and DMSA have been shown to reverse systemic autoimmune disease in rats. Both DMPS and DMSA have sulfur which binds very tightly to mercury. DMPS has at least three advantages over DMSA. First, it appears to remain in the body for a longer time than DMSA.
Secondly, it acts more quickly than DMSA, probably because its distribution is both intracellular and extracellular. Thirdly, preparations of DMPS are available for intravenous or intramuscular use, while DMSA is available only in oral form.
DMPS does not cross the blood brain barrier, or the barrier into certain body areas that are “compartmentalized” and are areas of low perfusion. Therefore, it will also be important to pretreat with cilantro so the mercury in the brain can be removed. MSM and chlorella should also be used for at least three weeks prior to initiating DMPS treatment. Combining high does of Chlorella with, before, during, and after the challenge test can dramatically increase the amount of mercury mobilized by the challenge and excreted out of the body.
DMPS is a prescription chemical that can be ordered by a physician through a number of compounding pharmacies. The dose is 3 mg /kg of body weight which is injected slowly intravenously over five minutes. This is followed by a 90 minute or 24 hour urine test for mercury. The dose is 3 mg per kg once a month and it is generally given in an equal amount of procaine 1% without preservatives. DMPS is expensive and may not be required to detoxify mercury. High doses of chlorella and cilantro are far more cost effective and have been found to be very effective in Germany for mercury detoxification. Intravenous DMPS should not be used in patients that still have silver amalgam fillings. The DMPS may chelate out significant amounts of mercury and precipitate seizures, cardiac arrhythmias, or severe fatigue. DMPS is not mutagenic, teratogenic or carcinogenic. Even though DMPS has a high affinity for mercury, the highest affinity appears to be for copper and zinc.66 If one uses DMPS, it will be important to supplement with the minerals to prevent a zinc or copper deficiency. One precaution is that DMPS should be given over a five-minute period since hypotensive effects are possible when given intravenously as a bolus.67 68 Other possible side effects include allergic reactions and skin rashes.
Sulfur Bearing Amino Acids
Sulfhydryl containing compounds have the ability to chelate metals. The sulfur containing amino acids methionine, and cysteine, cysteine's acetylated analogue N-acetylcysteine (NAC), S-adenosylmethinoinine, alpha-lipoic acid, other salts of succinic acid such as magnesium succinate, and the tripeptide glutathione all contribute to the chelation and excretion of metals from the human body.69 One of the sulfur bearing amino acids appears to be particularly useful in mercury detoxification.
Redoxal consists of dl-methionine and the typical dosage is one to two capsules before each meal.
DMSA and NAC
DMSA (meso-2, 3-dimercaptosucccinic acid) is a form of succinic acid but is a synthetic chemical not normally used in its routine functioning biochemistry. It is a much more effective mercury chelating agent then d-penicillamine.70 71 It is the only chelating agent other than cilantro and d-penicillamine that penetrates brain cells.
The dose is of DMSA is 500 mg twice a day for two weeks. The DMSA is then stopped for two weeks and then the cycle is repeated. In children, the dose is one half the adult dose (250 mg for six year old, while a two year old receives 125 mg DMSA). Patients six years or younger seem to do much better with DMSA relative to DMPS. The average adult needs about two years on this protocol. DMSA 500 mg tablet if written as a prescription, . MSM will help move the DMSA out of the kidney. One should do a urine mercury level by collecting at 90 minutes. It is important to recognize that the sulfhydryl compounds in DMSA will make the urine smell very sulfurous. It is helpful to communicate this to the patient so they are not taken by surprise.
Hyaluronic acid is a major carbohydrate component of the extracellular matrix and can be found in the skin, joints, eyes and most other organs and tissues. It has a simple, repeated disaccharide linear copolymer structure that is completely conserved throughout a large span of the evolutionary tree, indicating a fundamental biological importance. Through its complex interactions with matrix components and cells, hyaluronic acid has multifaceted roles in biology utilizing both its physicochemical and biological properties. These biological roles range from a purely structural function in the extracellular matrix to developmental regulation through effects of cellular behavior via control of the tissue macro- and microenvironments, as well as through direct receptor mediated effects on gene expression.73 Hyaluronic acid is utilized in many chemotherapy protocols as a potentiating agent.74 Hyaluronic acid is also being utilized for many novel applications in medicine.75 76 Personal experience has shown that the addition of 2 ml with the DMPS tends to improve the excretion of mercury by two-fold. There is virtually no toxicity with this agent.
The primary target organ in which inorganic mercury accumulates and expresses toxic effects is the kidney. There is a danger that the mercury may lodge in the kidney, which may damage it if appropriate measures are not taken.72 Homeopathic drainage remedies are helpful to allow the mercury to pass through the kidney and minimize potential toxicity. One of the commonly used remedies would be Solidago. Once extracellular detoxification is completed there are a number of effective homeopathic heavy metal or mercury remedies that are also useful.