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Nov 21, 1907-Feb 11, 1998

Dr. Josef Issels is regarded throughout the world as the Father of Integrative Medicine. His "Hypothesis of the Pathogenesis of Cancer, Chronic, and Degenerative Diseases" is the algorithmic template which guides the integration of alternative, complementary, and standard treatments by physicians. Two independent retrospective epidemiological reviews confirmed that Issels consistently cured many exhaustively pretreated and hopelessly advanced cancer patients during his forty years as head of a hospital for incurable cancer patients.

The focus of integrative medical care is the individual patient – the implementation is two-fold, comprising

  1. both standard and unconventional methods directed at the elimination of malignant cells as well as
  2. a system of non-specific immunological treatment modalities aimed at the restoration of the internal milieu and enhancement of the natural defense and repair mechanisms of the whole person.

According to Corinne Vizcarra , D.D.S. Oral Surgeon . "Dr. Issels provides what can be regarded as a 'blueprint' for our understanding of all chronic disease in his theories on the pathogenesis of disease.

Dr. Issels was the subject of a 1970 BBC documentary entitled "Go Climb a Mountain." BBC researchers concluded that the results of two independent epidemiological chart reviews had confirmed the cure of many cases of advanced cancer. A.G. Audier reported a 16.6% cure rate in 252 histologically verified Stage IV metastatic malignomas by the Issels comprehensive immunotherapy even after all conventional methods were exhausted (world wide cure rate is 2%). Using the same exclusion criteria, John Anderson, M.D., reported 17% cures of histologically verified metastatic malignomas all Stage IV, by the Issels comprehensive immunotherapy. The study comprised 570 patients, 87% of which were alive and disease-free after 5-years.

Josef M. Issels, MD, became internationally known for his remarkable rate of complete long-term remissions of "incurable cancers" in patients who had exhausted all standard treatments, such as advanced cancers of the breast, uterus, prostate, colon, liver, lung, brain, sarcomas, lymphomas, and leukemias. After completion of Dr. Issels' treatment, these patients remained cancer free for up to 45 years, leading normal healthy lives. Dr. Issels' treatment also significantly reduced the incidence of recurrent cancer after surgery, radiation, and chemotherapy, thereby considerably improving cure rates.

Dr. Vizcarra states that “it was my privilege to work with Mrs. Mary Issels Clinic in Tijuana B.C. Mexico , for several years . Dr. Issels Protocol taught me will remain with me as part of my practice forever. He was a genius and humanitarian and I have deep respect for him as a human being.

MAXILLOFACIAL FOCI REVIEW - This set of diagnostic procedures includes the biological dentist and several surgeons. In the mouth, cavitational lesion , root canals, devitalized teeth, and silver amalgams , heavy metal crowns are considered. In the nose and throat, sinuses, tonsils, and adenoids will be examined.

FOCI OF INFECTION - From the first tonsillitis - causing respiratory infections of infancy - and from the first cavities in baby teeth – strep and staph bacteria and other infections smolder chronically in both tissue and bone. Issels taught that infections in the mouth , teeth, jawbones, tonsils and adenoids are the longest standing (since early childhood) immune suppressing influences common to almost all cancer patients.

Surgical removal of chronically infected tissue as cavitational lesion and root canal filled tooth and bone frees , the immune system, giving far-advanced patients another chance to fight the disease from within. For example, in 1972 a consecutive sample of 462 cancer patients underwent tonsillectomies at Issels, Ringberg Klinik. An independent and highly regarded pathology laboratory confirmed that every single pair of tonsils was diseased with infections, atrophy, hyperplasia and even malignancies. After the institution of routine foci removal (including root canalled teeth and cavitational lesion ), the rate of deaths due to cardiac co-morbidity’s in the Ringberg Klinik fell dramatically and the rate of cures increased concomitantly.

THE “ FOCUS “ HAS BEEN DESCRIBED AS A CHRONIC, ABNORMAL , LOCAL change in the connective tissue, capable of producing the most varied distant effects beyond its immediate surroundings, and therefore in constant conflict with local and general defense ( Pischinger and Kellner ). By this definition, even a fully-healed scar may sometimes act as a focus, spreading disease to distant parts of the body. But the foci we shall now examine will be confined to those of the THEET and tonsils - in my view, the most lethal of all foci .

The emphasis I place on the REMOVAL OF DEVITALIZED TEWTH and chronically – diseased tonsils in one of the better-known aspects of my work, but also one of the most criticized and misunderstood. I do not , for instance, recommend that healthy tonsils and teeth be removed from a healthy person. But I believe if they are diseased, they cause the body’s natural resistance to be lowered, thus acting as an important contributory factor to tumors development. In these cases, I insist on their REMOVAL.

It is sometimes argued that to carry out such operations on seriously ill patients is unnecessarily cruel, even irrelevant. There are some unpleasant side- effects, but in my opinion, the benefits- which I will describe- more than make up for any temporary discomfort. It is further argued that in the cancer patient, as much lymphatic tissue as possible should be preserved, and that therefore tonsillectomy should not be carried out because even a diseased tonsil may retain some useful defense potential. I used to believe this as so. I do not any longer for reasons which will become evident.

In addition, my experience shows a direct connection between dental and tonsillar foci and many of the illnesses responsible for early debilitation and untimely invalid sing.

It has long been generally accepted that head foci may give rise to almost all kinds of chronic, and certain acute diseases, such as- to mention a few- the manifold varieties of rheumatic and cardiovascular conditions. The removal of such foci is today a routine art in the conventional treatment of those diseases. However, the fact that head foci are also a contributory cause in the development of neoplasia, by lowering resistance, has received all too little acknowledgement.

The extent of the disease- provoking activity of a focus in distant parts of the body depends on whether the body is able to oppose the focus with its own defense mechanism . As long as the focal situation is kept under control by the local defense mechanism , no focus- induced remote effects will arise. On the other hand, distant effects will arise when the body’s resistance has more or less broken down: contro of head foci wil then gradually collapse, , and there will be a consequential gradual increase in generalized focogenic intoxication. This will cause an inevitable deterioration of the body’s defense power with a concomitant promotion of malignant growth.

Nearly everybody is confronted with DENTAL PROBLEMS at some time in their life, and even the most scrupulous dental care can not guarantee dental health. Endogenous factors, such as prenatal damage to the embryonic dental tissue, as well as exogenous influences, such as malnutrition and toxins, must essentially be held responsible for the great number of dental diseases, be they a weak, susceptible gingival, or gum; or teeth which are mal positioned, barreled or impacted; or worst of all, a disposition “ to decay “ .

Despite its porcelain-like surface, the crown enamel of the tooth is vulnerable to decay. Enamel defects develop especially in the grooves of the crown or on the adjacent surface of neighboring teeth which are difficult to clean.

Decay is not painful so long as it is confined to this nerveless enamel layer. The onset of a toothache is the first noticeable sign that the decay has invaded the dentine body of the tooth which, unlike the enamel, does have nerves. If this decay is allowed to continue, sooner or later the dentine will be completely penetrated, and the pulp ( nerve ) inside the tooth will then become inflamed.

As long as only the outer enamel and dentine are affected, the tooth can be preserved. But a tooth with an inflamed pulp ca no longer be saved, and must be extracted without delay.

In an understandable desire to preserve as many teeth as possible , to maintain the masticator apparatus and its functions, attempts are often made to save teeth which are in fact lost. There is a widespread conviction that this can be done without risk by the sterile evacuation of the pulp, and then refilling the cavity. For decades, the erroneous belief was held that, after such treatment , the tooth is an isolated, lifeless thing, no longer involved in any of the body’s processes. This assumption was originally based on the premise that the pulp cavity had only one orifice to the apex of the root below, and by filling, this opening was sealed. However, the dentinal canal does not end in just one opening; instead, it resembles a tree with many branches which penetrate the tooth’s body in all directions.

The finer details of the entire dental structure have been exhaustively studied by Austrian researches. They have established that there is a lively metabolic interchange between the interior and exterior milieu of the tooth , and that this two- way process takes place along many thousands of hyperfine, capillary canals joining the pulp cavity to the exterior surface of the tooth. Very careful conservation measures may possibly seal of the vertical central-medial-tube of the dentinal canal, but, it will never reach the lateral “ twigs” branching off from this tube. Nor can it ever close off the innumerable capillary canals. Some protein will always remain in these secondary spaces. If this protein becomes infected, toxic catabolic products will be produced, and conveyed into the organism.

It was established in 1960 by W. Meyer (Gottingen) that within devitalized teeth the dentinal canals and dental capillaries contain large microbial colonies. The toxins produced by these microbes in a tooth with a root filling can no longer be evacuated into the mouth, but must be drained away through the cross- connections and unsealed branches of the dentinal and capillary canals into the marrow of the jawbone. From there, they are conveyed to the tonsils, and thus the flow systems of the body. In fact, the conservation treatment may literally convert a tooth into a toxin producing “ factory “.

A devitalized tooth is no longer able to perceive and control inflammatory processes even when suppuration has invaded the surrounding bone spaces of the tooth’s socket; it rarely gives warning signals , for instance through pain , and therefore there is nothing to induce the patient to have this dangerous toxic foci removed. It then may7 be left to develop its devastating affect on the organism for decades or even for a lifetime.

When the inflammation spreads to the marrow of the tooth socket, it can cause Osteomyelitis. Its further course is determined by whether and for how long the local defense is able to keep the focal disturbance under control.

If the body’s local resistance is intact, The inflammation is enclosed by a capsule of connective tissue known as the DENTAL GRANULOMA. This membranous cyst prevents its toxic from spreading into the organism. Radiographs of these teeth show granuloma cysts as more or les marked transparencies , showing a darker irregular radiolucent area on the apex of the root. This type of tooth is called X- Ray positive.

If the body’s local resistance is weakened to such an extent that the inflammatory process cannot be encapsulated by the granuloma cyst, the toxins will be able to advance unhindered into the marrow space, the tonsils, and into the body. In this case, it is proof that, as stressed by Pischinger and Kellner - the organism has become largely incapable of reaction . Radiographs of these teeth as a rule show no transparencies, and are therefore called X- Ray negative.

In my cancer patients, I have found that such non –encapsulated foci- that is those who show X-ray negative- were particularly common, as one would expect from people whose body resistance had been lowered.

Today there is general agreement that dental foci should be cleared away, and it has become usual to diagnose them by X.-ray . Unfortunately only some of the dental foci ca be discovered by this means. Encapsulated foci can be recognized only if large enough , and if not concealed by the tooth’s shadow. And definite X-ray signs are much rarer in non-encapsulated Osteomyelitic processes . It is therefore the most dangerous of all dental foci which most frequently prove X-ray negative. Even with X-ray positive dental film only those foci can be recognized which happen to be situated outside shadows . Ince X-ray negative foci often escape treatment- and they are the ones the body has failed to resist effectively - the can continue to develop thedir destructive effects unhindered .

My clinical experience has produced evidence of a causal connection between foci and tumor development, and in this respect , the results obtained with the aid of an infra- red test are especially significant Any inflammatory disease focus creates on its corresponding skin surface a pathological increase of infra- red emission ; the higher the activity of the focus, the more pronounced it is. Using an infra- red sensitive instrument (Schwamm’s infra-red toposcope ) the intensity of this emission ca be continuously monitored and measured. Observation showed a close interrelation between the infra-red emission of head foci and that of the neoplasial region. That is, after treatmenty, a decrease in the infra- red activity of dental foci was as a rule accompanied by a decrease in infra- red emission over the tumor areas.

From this it is clear that the advisable treatment for devitalized teeth is SURGICALLY EXTRACTION .

But even this is not always enough. My experience has further shown that also living teeth may sometimes be so damaged that their pathogenic potential almost equals that of devitalizes teeth . For instance, latent chronic pulpitis ( pulp inflammation ) may arise in a tooth that appears out –wordily healthy , thus having a focal effect.

The diagnosis and treatment of dental foci remains generally unsatisfactory . A survey conducted at my clinic found that , on admission , ninety- eight percent of the adult cancer patients had between two and ten dead teeth, each one a dangerous toxin producing “ factory” Very often we are confronted with X- ray , negative dead teeth, root remnants , and residual osteitis ( Cavitational Lesion ‘NICO’ ) which had not been diagnosed and therefore had not been removed.

Only total, thorough dental treatment will really succeed in giving the body’s defense a chance. In addition to X-ray diagnosis, it is therefore necessary to use other diagnostic aids. Such as infra-red techniques tests, to estimate tooth vitality and periosteal resistance, and other electrometric methods .

The diagnosis of foci in teeth has been greatly improved by electro acupuncture, Is s now possible to differentiate foci no only with regard to their type and position, but also to their virulence and pathogenic efficacy. The result of focus treatment can consequently be observed and improved, before, during, and after dentistry , to an extent never known before ( Kramer).

If total treatment is to be performed, it is necessary to remove not only any devitalized teeth but also any hidden dental foci remaining in the jaw. Further, total removal of devitalized teeth and their roots must not be the end of the dentist’s activities. Each alveolus, - the tooth’s socket in the jaw-should be radically cleared down to the healthy bone. In that way the development of a residual osteitis ( Cavitational Lesion “NICO”) or of a cystoma may be prevented. It Is not only the tooth which may be a focus, but the adjacent tooth –fixing apparatus as well. There are four different ways by which dental foci - and indeed all foci- can affect the organism and contribute to the development of secondary damages:

  1. The “neural“ way of affecting the organism. When a focus develops anywhere in the transit tissues , the mesenchyme, the process is centripetally projected from the terminal neural organs around the irritated area, along the neural ducts, up to the corresponding control cells within the central nervous system. The irritation origination from a focus ca, under certain conditions, trigger of the mechanism of a neural dystrophy a slow degeneration which my show itself in localized effects in other areas, but also in a generalized dystrophy disturbance. In the 1950 it was shown that these manifestations are based on depolarizing processes in the effected neural cells, and in the corresponding tissues of the body’s periphery. ( Fleckenstein and Ernsthausen ) By elimination of the focus, the affected tissues may be repolarized, The most striking example of this repolarization is called “ second-phenomenon “ Ferdinand Huneke, the founder of neural therapy whose remarkable contribution in this regard we shall look at in detail later, discovered over forty years ago that injection of a local anesthetic near a primary focus may immediately remove any symptoms of distant disease induce by the focus. This effect - the second-phenomenon –usually takes place only in those a few seconds after the anesthetic injection and lasts for hours, days, or even for a life time. Naturally the improvements occurs only in those regions influence by the injected focus. Nevertheless , the measure has therefore a remarkable diagnostic value as well. Since neural therapy only neutralizes the neural effect of a focus, the focus itself must , of course, be removed after such treatment, in order to eliminate its latent toxic or allergenetic action. Conversely, any focal surgery must be followed by desensitizing and neural-therapeutic measures. The only exceptions to this rule are, for instance, featureless scars of other spots with no inflammatory change which produce only neural distant effects without at the same time causing any toxic, microbial or allergic secondary phenomena .
  2. The “toxic way“ of affecting the organism . The toxic activity of odontogenic foci is probable far more perilous for the organism than their neural effects. The mechanism of this distant toxic activity , as well as the characteristics of e toxic compounds involved have been largely ascertained. Odontogenic compounds are the gangrenous contents of an inflamed . Commonly found in tissues destroyed by inflammation, liquefaction and microbial putrefaction. Thus there ca be little doubt that they are genuine necrogenous toxins, including for instance autologous protein and higher- molecular proteinogenous compounds. 3Later there will be produced numerous low-molecular fission products resulting from enzyme cleavage and other biogenic conversions . The identity and chemical structure of certain of the biogenic amines were mainly clarified in the 1950 by Schug-Koesteris , Hiller, Gaebelein and others of the University of Munich. Following similar findings in America, the metabolic and exchange processes in solid dental structures were further investigated by the German researcher Spreter von Kreudenstein. He showed that drugs injected intravenously were, four to five hours later, discernible within the intra dental capillary ducts or even devitalized teeth, and in a concentration only slightly lower than in the blood. All these findings prove conclusively that within solid dental structures , there may proceed an unimpeded substantial interchange in either direction. Consequently, odontogenic toxins, wherever they may have been produced, are able to diffuse and circulate within the organism. The pathogenic significance of these, “endotoxins “ has been investigated by the German study group of Eger-Miehlke . They examined the changes in healthy experimental animals after injection of accurately defined, minimal quantities of the endotoxins from an “ Odontogenous Granuloma “ . A single injection of a minimal dose seemed to develop a defense activating effects. But after repeated injections, there was severe liver damage, and the animal died within weeks. Apart from the fatal liver damage, inflammatory and degenerative changes were found in al other organs, especially in the joints, muscles, and blood vessels. These results brought clear experimental proof for the first time that focogenic toxins act as causal agents for severe diseases in animals corresponding to similar chronic conditions in man. The most dangerous of all odontogenous toxins are undoubtedly the thio-ethers, for instance dimethylsulfide . In a series of test performed at my clinic, it was observed that patients with odontogenous and tonsillar foci had a heightened level of dimethylsulfide in their blood. After intensive treatment of the foci , this level returned to normal in just a few days.

Thio-ethers are closely related, both in their structure and their effect, to mustard gas and other poison gases used in the First World War. The extreme toxicity of the poison gases and thio-ethers can be attributed to the following properties :

  1. They are weakly basic, therefore “ electro-negative” and thus they are deposited particularly in “electro-positive” cells such as those of the transit tissues as well as those of the defensive tissues.
  2. They are soluble in the lipids , and therefore have a pronounced tendency to enrich themselves in the lipoid- containing cellular structures, especially in mitochondria.
  3. These subcellular organelles, attached to their lipoid membranes, contain the enzymatic structures responsible for the maintenance of aerobic metabolism a precondition for full functioning power in all the body’s cells and tissues. If these indispensable units are damaged the most serious consequences will follow. Because they are themost vulnerable cellular organelles , mitochondria are a favorite and almos exclusive target for thio- ethers.

    The action of thio- ethers is effected in three main ways:

    1. since thio- ethers tend to combine with electro- positive metal ions and many bio-elements which act as co-effectors or activators of numerous enzymes ob absolutely vital importance, and as our present-day average diet is deficient in essential substrates such as vitamins and bio-metals, this deficiency is enhanced. Much of the daily intake of bio-metals, usually deposited in the fluids of a focally affected organism. Will be made permanently ineffective, the more foci the greater will become the deficiency.
    2. Thio-ethers are “ partial “ antigens, haptens, and thus they also tend to combine with the normal proteins in the body, “denaturizing “ them. Such denatured proteins become “non-self” agents which the body must deal with as such. The production of antibodies adapted to the situation will be provoked, and they will home in on the target antigens wherever they are. The process of “ auto-aggression “ will be set in motion: self-destruction of agents alien to the organism. Extensive structural cellular damage will result, increasing with age.
    3. The famous biologist , Otto Warburg , twice winner of the Nobel Prize, has shown that aerobically - blocked cells – as caused by thio-ethers- will increase their anaerobic metabolism in an attempt to maintain their vigor. In doing so, they acquire the characteristics of malignant cells. Therefore, chemical agents capable of inactivating the aerobic process while increasing the anaerobic process are usually classed as carcinogenous compounds .


    Druckrey ( Heidelberg ) found inter alia that transformation of a normal cell into a malignant cell requires a certain quantity of a carcinogen - the carcinogenic minimum dose. It does not matter whether this quantity is supplied in a single dose or in a number of smaller doses, because the toxic effects of each dose are stored, and accumulate without loss. The carcinogens held primarily responsible for the development of spontaneous cancer in man are those: which inhibit the aerobics even in minimal quantities without at the same time immediately destroying the cell, and which are constantly present in the organism in this minimal concentration of either endogenous or exogenous origin; they can therefore accumulate during the normal life expectancy gradually and unnoticeably until the total quantity necessary for maligners is reached . There is hardly a carcinogen which so completely fulfils these conditions as do thio- ethers. Incessantly, from the moment the pulp is removed , hour by hour, year by year , minimal amounts of these most virulent of all the odontogenous toxins will be released into the circulation –minimal doses, but nevertheless sufficient to more or less totally paralyze the aerobic action of the cell . The nervous system is thus doubly affected by focal intoxication .

    Intoxication of neural cells caused by the toxins spreading through the liquid vehicles of the flow systems , such as the blood and lymph . The more mitochondria a cell contains , the more it will be damaged by the enzyme- inhibiting effect of thio-ether compounds. Therefore it is the vital organs, the liver, nervous system, endocrine glands, heart, and reticuloendothelial system - whose cells my consist of up to one-fifth of mitochondria, that are primarily affected. Apart from disturbing regulatory control, odontogenous toxins will also cause additional damage almost throughout the body. Naturally , the higher the blood- level of foco genous toxins, the more severe will be their effect.

    The close interlacing of the lymphatic and endocrine systems in the head, make it unavoidable that brain cells are more intensively toxicities by the circulating focogenous agents and may suffer particularly heavy damage. The lymph ducts of the had region join Waldeyer’s tonsil ring where detoxification takes place. There, inflammatory swellings inevitable cause a lymphatic congestion. All the toxic sewage of head foci are channeled into Waldeyer’s tonsil ring, and if there is such congestion, waste fluids will be pressed through the porous base of the skull into the lymphatic space of the brain. Toxogenous changes, especially within autonomic nuclei , are regularly found in cancer patients. As verified in the q930 by Muehlmann (Moscow ) and they may be a consequence of a life-long inhibition of cerebral aerobics due to focogenous intoxication. The cerebral damage (diencephalosis ) and the subsequent loss of vitality in cancer patients is accompanied by a number of other symptoms. The emission of hypothalamic energy impulses , recordable by a Voll’s electro- acupuncture device, are reduced in patients with focal disease. The autonomic vigor is relaxed, creating “ regulation rigidity “ carcinomas tend to parasympathicotonic derailment ; in sarcomas and systemic diseases, as a rule the opposite is found- sympathicotonic derailment (Regelsberger, Gratzl-Martin, Rilling et al ) The diurnal, circadian regulation of the acid-base balance is lost ( Sander) . At the same time , there will exist a distinct inhibition of other diurnal control functions, for instance of blood sugar, cholesterol, and mineral metabolism, and many other metabolic parameters are greatly restricted ( Hinsberg).

  4. The “ allergic” way of affecting the organism . The toxic effects of thio-ethers ( Root Canal and Cavitatrional lesions ) overlap those caused by higher- molecular odontogenous toxins, as already described. Antibodies are formed to fight these substances, eventually leading to the destructive processes in toxified cells. Since the organ- destroying antibodies or defense enzymes are excreted by the kidneys, they can be diagnosed in the urine by the Abderhalden test. In this way we can precisely deduce , in most cases, which organs have suffered secondary damage (Abderhalden, Dyckerhoff et al ). The extent of secondary lesions can also be demonstrated indirectly by vaccine treatment. Using desensitizing vaccines made from focogenous agents, reactions are caused in regions affected by distant focal effects which may become evident in regional as well as general symptoms.

    It is thus clear that the development of cancer disease, is in more ways than one, closely linked with focal events.

  5. The “ Bacterial “ way of affection the organism. Bacterial dissemination from primary “ Dental Foci “ as a rule takes place with barely perceptible symptoms, and may be followed by the formation of “ Secondary Foci “ in other regions. These include, inter alia , Foci in the Paranasal sinuses, gall- bladder, appendix, prostate and renal pelvis. Above all, bacterial dissemination tends to produce micro foci or micro thrombi in veins , and they in turn have a tendency to thrombosis or thrombus phlebitis, possibly with concomitant embolism. Thrombus phlebitis and thrombosis, so common in cancer patients, and generally regarded as resulting from disordered metabolism, are due not only to the dyscrasia of those patients, but also to the manifold effects of “ Dental Foci “ We have now seen how decisively the entire organism is affected by “Dental Foci” not properly treated, and what catastrophic results destruction of the pulp may entail. Dentists must, therefore bear in mind that there is no root treatment which does not inevitably produce foci. The dentist’s task is l only secondarily cosmetic; primarily it must be preventive and curative. The over- riding consideration must not be conservation of the tooth but preservation of its vitality. If this is impossible , even the most beautiful crown must not delude us that the lifeless tooth beneath is anything other than a “ corpse in a golden coffin “ whose decomposition toxins slowly but surely are destroying the organism (Bircher-Benner ). Other foci in the jaw, for instance Cavitational Lesion Osteitis Residual , Osteitis, cysts, foreign bodies, gingivitis, and malposition of teeth may also develop focal effects. It goes without saying that these foci , disturbance fields and centers of irritation must be removed . The dentist should always remember that he has a vital role to prevent the development of chronic illness and , most important of all to decisively reduce the hazard of cancer .